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Bar Harbor, ME 04609
Scientist, PostDoctoral Associate, Professor/Faculty
The Munger Lab (mungerlab.com) is seeking a postdoctoral associate to join our growing interdisciplinary team in Bar Harbor, Maine. Our systems genetics research program explores the interface between genetics and the environment, and how complex interactions between the two can push gene regulatory networks that drive normal cell differentiation and organ development to an altered disease state. Specifically, we take advantage of powerful, genetically diverse mouse populations (Diversity Outbred and Collaborative Cross) and stem cell lines to study how genetic variation in the population impacts multiple layers of gene regulation genome-wide, with an emphasis on post-transcriptional processes that modulate protein levels independent from transcript abundance. Postdoctoral associates lead their own projects as well as participate in larger collaborative efforts involving multiple investigators, and given the current uncertainty surrounding the COVID-19 pandemic, postdocs may be expected to work remotely for a significant portion of their time. Consequently, being able to work independently and as part of a (remote) team will be essential to success in this role.
The successful candidate will integrate large genetic and multi-dimensional genomic datasets from bulk tissues down to individual cells to (1) infer the gene regulatory networks responsible for maintaining pluripotency and driving cell fate decisions; (2) identify key components of these systems that are particularly sensitive to genetic variation; and (3) define the genetic basis for cellular heterogeneity in these processes. The postdoc will take advantage of existing methods used by the lab, including quantitative trait locus mapping and mediation analysis, and will also be encouraged to develop novel computational approaches to achieve these goals. Candidates with experience at the bench will have the opportunity to validate their computational predictions with mice or cell lines in our wet lab.
The Munger Lab strives to be an open, collaborative, diverse, and supportive scientific environment, and all members of the lab are expected to do their part to achieve these goals. Dr. Munger is committed to providing post-doctoral associates and graduate students with the interdisciplinary training necessary to be successful independent scientists in the genomic era. Munger Lab members are encouraged to participate in outreach and education opportunities, and to be active citizens in their scientific and local communities.
The Jackson Laboratory (http://www.jax.org) is recognized internationally for its excellence in research, unparalleled mouse resources, outstanding training environment characterized by scientific collaboration, and exceptional core services – all within a spectacular setting adjacent to Acadia National Park. Translational research collaborations in genomics-based, personalized medicine are fostered through our JAX Genomic Medicine campus in Farmington, CT. In addition to lab-based training, JAX has developed a unique program for trainees to expand their professional skills in science communication, entrepreneurship, teaching, mentoring and laboratory management to best prepare postdocs for future career opportunities.
The Jackson Laboratory provides excellent educational and training opportunities for postdoctoral associates. Exceptional candidates are encouraged to apply for the prestigious JAX Scholar award, which supports promising early-career postdoctoral associates conducting cutting edge biomedical and basic biological research at JAX. The award includes an independent research and travel budget and a salary above our standard postdoctoral scale (https://www.jax.org/education-and-learning/pre-and-postdoctoral-program/jax-scholars.
Plan, develop, analyze, and execute an independent research project.
- Work within a collaborative team to develop novel algorithms for integrating and analyzing genetic and genomic data.
- Apply existing and novel algorithms, analyze data quality, critically review and analyze results, communicate results to team members.
- Follow reproducible coding and experimental practices
- Contribute to scientific writing and creation of data figures to be included in research publications.
- Ph.D. in bioinformatics, computational biology, biostatistics, or a Ph.D. in biological or related sciences with demonstrated computational training is required.
- Proficiency in R and Python programming languages is highly preferred.
- Training and experience in genetics, systems genetics, genomics, systems biology, molecular biology, stem cell biology, and/or developmental biology is preferred.
- Applicants are not required to have previous experience working with mouse models or data. Applicants with experience in human genetics or other model organisms are encouraged to apply.
- English language fluency.
- Exceptional verbal and written communication skills are required.
- Demonstrated self-motivation and independence, with the ability to excel in a highly collaborative research environment.
- Demonstrated writing ability as evidenced by significant contribution/leadership role in bringing a minimum of one 1st author paper from graduate work to publication.
To apply, please submit (1) a cover letter outlining research accomplishments and interests; (2) a current CV; and (3) names and contact information for three references.
The Jackson Laboratory (JAX) is an independent, nonprofit biomedical research institution with more than 2,300 employees. Headquartered in Bar Harbor, Maine, it has a National Cancer Institute-designated Cancer Center in Augusta, Maine, a genomic medicine institute in Farmington, Connecticut, and facilities in Ellsworth, Maine, Sacramento, California, and Shanghai, China. Its mission is to discover precise genomic solutions for disease and empower the global biomedical community in the shared quest to improve human health.
The Jackson Laboratory’s 43-acre scenic Bar Harbor campus is nestled between the Gulf of Maine and the mountains of Acadia National Park. Some of the best hiking and biking in the world (over 50 square miles of mountains, lakes, views, and dramatic coastline) is accessible from our campus. We are one mile from downtown Bar Harbor, which offers a vibrant downtown district with a plethora of restaurants, shops, museums, and galleries.
JAX employees work in a collaborative, value-driven, and team-based environment where the focus is on advancing science and improving patients’ lives. Researchers apply genetics to increase the understanding of human disease and advance treatments and cures for cancer, neurological and immune disorders, diabetes, aging, and heart disease. JAX was voted among the top 15 “Best Places to Work in Academia” in the United States in a poll conducted by The Scientist magazine!
INTEGRITY – Courage and commitment to do what is right
PEOPLE – Inspiring our people to enhance the health of all
ONE TEAM – Unified by our promise to transform medicine and science
EXCELLENCE – Achieving world-class results
INNOVATION – Leading with discovery and creative solutions
STEWARDSHIP – Caring for and enhancing the resources entrusted to us
What do we have to offer?
JAX offers a dynamic and supportive work environment, competitive salaries, and a comprehensive benefits… For full info follow application link.
All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, disability or protected veteran status.